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“Science needs a lot of study, as knowledge of it is infinite, but principles should be described in a simple way, in the grasp of everyone. Otherwise it is nothing!”
The Everlasting Pupil.
These diseases are very common and concern many patients, especially with advancing age.
Common cause is diabetes and metabolic syndrome, which involve predominantly thin nerves in the periphery, that is principally in the legs. (Polyneuropathy of long ones.)
Borreliosis is prevalent over large territories in temperate climates, and with distinguishable features by ultrasound, interesting thicker nerves, sensitive as well as motor ones, without special predilection (Mononeuritis multiplex.)
Echography readily shows focal thickenings of involved structures.
This last-mentioned entity englobes also the arteritis frame, like polyarteritis nodosa, Wegener’s, Churg-Strauss and so forth, as well as Gammopathies for instance.
Here should be noticed also frequency of giant-cell arteritis, like the so-called temporal one, or polymyalgia rheumatica.
Vessel walls, being constructed to biggest percentage of lipids, it is not unlike that a deficit in essential fatty acids, especially Omegas 3 and 6, leads to those ailments. (Perhaps other ones, like Omegas 9 and 7, are also not unimportant.)
Here I would like to underline the fact that modern nutrition in industrialized society is largely deficient in Omegas 3 and 6.
Thus, this could also give rise to neural illness.
Vitamins B12 and 9 (folic acid) are abundant in our nutrition, but with advancing age first one is poorly absorbed from small bowel, as it needs to combine to the so-called Intrinsic Factor secreted by the stomach.
Unfortunately, most prevalent autoimmune disease consists of parietal stomach cells degeneration.
Here also, early diagnosis is essential, as late cases of polyneuropathy are said irreversible. (Which I personally doubt.)
For diagnosis you need measurement in blood of methylmalonic acid or homocysteine.
Some evidence indicates that Mycoplasma pneumoniae (Common Cold) constitutes also a possible etiology.
Paraneoplastic syndromes are well known.